At Intellectra, we conducted extensive research and testing to craft the ideal blend of ingredients and dosages. Below are some of the key studies that shaped our formula and guided our decisions.
LION'S MANE MUSHROOM
A fungus native to forests in Asia, North America, and Europe, Lion’s Mane has been traditionally used in herbal medicine for its potential to support neurological health.
Research suggests it may promote the production of nerve growth factor (NGF), which is involved in the maintenance and regeneration of neurons, potentially supporting long-term cognitive function.
The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study
Summary:
This double-blind, placebo-controlled study demonstrated that Lion's Mane mushroom supplementation improved attention and processing speed shortly after a single dose, with a trend toward reduced stress levels after 28 days of use.
These findings suggest that Lion's Mane supports cognitive performance and stress management, making it an essential ingredient in Intellectra for enhancing focus and resilience under pressure.
Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study
Summary:
This double-blind, placebo-controlled study investigated the effects of Erinacine A-enriched Hericium erinaceus (Lion's Mane) in patients with mild Alzheimer's disease. Results showed improved cognitive function and delayed disease progression, highlighting its neuroprotective properties.
These findings justify Lion's Mane as a key ingredient in Intellectra, supporting cognitive health and long-term brain function.
Neurotrophic and Neuroprotective Effects of Hericium erinaceus
Summary:
This study highlights the neuroprotective and neurotrophic effects of Hericium erinaceus (Lion's Mane), showing its ability to stimulate nerve growth factor release, regulate inflammation, and protect nerve cells from oxidative stress and apoptosis.
These findings reinforce the inclusion of Lion's Mane in Intellectra for supporting brain health, reducing oxidative damage, and promoting long-term cognitive resilience.
Link to study
Therapeutic Potential of Hericium erinaceus for Depressive Disorder
Summary:
This study reviewed the therapeutic potential of Hericium erinaceus (Lion's Mane) for depressive disorders, highlighting its ability to promote nerve growth factor expression and reduce inflammation. The findings suggest it may serve as a natural alternative for mood enhancement and stress reduction.
These properties validate Lion's Mane as a critical ingredient in Intellectra for supporting emotional well-being and cognitive health.
BACOPA MONNIERI
A revered Ayurvedic herb, Bacopa Monnieri has been used for centuries in traditional Indian medicine to enhance memory, mental clarity, and learning ability.
Modern research confirms its neuroprotective benefits, supporting long-term cognitive resilience and stress reduction, ideal for high achievers and deep thinkers.
Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial
Summary:
This randomized, double-blind, placebo-controlled trial evaluated the effects of Bacopa monnieri on cognitive performance, anxiety, and depression in elderly participants over 12 weeks. The results demonstrated improved memory retention and reduced anxiety levels, highlighting its role in cognitive enhancement and emotional support.
This was used to justify the inclusion of Bacopa monnieri in Intellectra to enhance memory and promote mental well-being.
Link to study
Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst - A review on its mechanistic aspects
Summary:
This review highlights the neuroprotective and memory-boosting effects of Bacopa monnieri, showing its ability to mitigate oxidative stress and improve cognitive performance through multiple cellular pathways.
The findings emphasize its potential for enhancing memory and intelligence. This supports Bacopa monnieri's inclusion in Intellectra to improve memory and protect against cognitive decline.
Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract
Summary:
This meta-analysis reviewed nine randomized controlled trials involving 518 participants and found that Bacopa monnieri significantly improved cognitive function, including memory and attention.
The study demonstrated enhanced information processing speed and choice reaction time. These findings support Bacopa monnieri's inclusion in Intellectra to enhance mental clarity and cognitive performance.
Neuropharmacological review of the nootropic herb Bacopa monnieri
Summary:
This review highlights Bacopa monnieri's neuroprotective and cognitive-enhancing properties, including its role in improving neurotransmitter modulation, reducing oxidative stress, and enhancing cerebral blood flow. It supports Bacopa’s use in attenuating cognitive decline and memory impairments.
These findings validate Bacopa monnieri as a safe and effective nootropic in Intellectra for boosting memory and protecting brain health.
L-THEANINE
A naturally occurring amino acid found in green tea leaves, L-Theanine is known for its ability to promote relaxation without sedation.
It influences alpha brain wave activity, which is associated with a state of wakeful calmness, and is often used to balance the stimulating effects of caffeine.
Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial
Summary:
This randomized, placebo-controlled study found that L-Theanine (200 mg/day) significantly reduced stress-related symptoms, improved sleep quality, and enhanced cognitive function in 30 healthy adults over four weeks.
Participants showed lower anxiety and depression scores, better sleep, and improved executive function and verbal fluency.
These findings support L-Theanine’s inclusion in Intellectra for promoting relaxation, focus, and mental clarity.
L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance
Summary:
This study investigated the combined effects of L-Theanine (100 mg) and Caffeine (50 mg) on attention and cognitive performance.
The results showed improved attention, target accuracy, and alpha brainwave activity when the two were combined, compared to either ingredient alone.
These findings support the inclusion of both L-Theanine and Caffeine in Intellectra for their synergistic ability to enhance focus and mental clarity.
A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood
Summary:
This double-blind, placebo-controlled study found that Caffeine and L-Theanine, both alone and in combination, improved attention, mood, and cerebral blood flow. The combination resulted in enhanced cognitive performance without the jitteriness often associated with caffeine alone.
These findings support the inclusion of both ingredients in Intellectra to promote sustained focus, mental clarity, and balanced energy.
ALPHA-GPC
A highly bioavailable source of choline, Alpha-GPC fuels the production of acetylcholine, the neurotransmitter responsible for learning, memory, and muscle control.
Backed by research, it enhances cognitive speed, mental clarity, and focus, making it a powerful brain-boosting compound for peak performance.
Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men
Summary:
This randomized, double-blind study found that supplementation with Alpha-GPC significantly enhanced cognitive performance, including attention and memory tasks, in healthy male participants.
The study demonstrated its role in maintaining choline levels and improving neurotransmitter function.
These results validate Alpha-GPC as a key ingredient in Intellectra for boosting focus and mental clarity.
Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study
Summary:
This randomized, placebo-controlled study found that Alpha-GPC supplementation increased motivation and self-reported emotional states in healthy volunteers. The results demonstrated its role in enhancing acetylcholine levels and supporting neurotransmitter systems related to reward and mood.
These findings support Alpha-GPC’s inclusion in Intellectra for improving motivation and emotional well-being.
The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility
Summary:
This randomized, placebo-controlled study found that Alpha-GPC supplementation improved cognitive function, focus, and mood compared to caffeine or placebo. It also supported physical performance by preventing exercise-induced reductions in choline levels.
These findings highlight Alpha-GPC's role in Intellectra for enhancing mental clarity and overall performance under demanding conditions.
HUPERZINE A
An alkaloid extracted from the Chinese club moss (Huperzia serrata), Huperzine A acts as an acetylcholinesterase inhibitor, meaning it helps preserve acetylcholine levels in the brain.
This has been studied for its potential to support memory retention and cognitive function, particularly in learning-intensive environments.
Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis
Summary:
This meta-analysis of placebo-controlled trials found that Huperzine A significantly improved cognitive function, memory, and daily activities in patients with Alzheimer’s and vascular dementia.
It was well-tolerated, with mild and transient side effects reported.
These findings support Huperzine A’s inclusion in Intellectra for enhancing memory and protecting against cognitive decline.
Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease
Summary:
This review highlights Huperzine A’s neuroprotective effects, particularly its ability to inhibit acetylcholinesterase (AChE), supporting acetylcholine levels crucial for memory and cognitive function.
The study also emphasizes its role in reducing amyloid-β accumulation and protecting mitochondria, key factors in neurodegenerative conditions like Alzheimer’s.
These findings validate Huperzine A’s inclusion in Intellectra for enhancing memory and safeguarding brain health.
Effect of Huperzine A on Cognitive Function and Perception of Effort during Exercise: A Randomized Double-Blind Crossover Trial
Summary:
This randomized, double-blind crossover trial tested Huperzine A (200 mcg) and found it acutely improved cognitive function during exercise in 15 trained individuals.
Results showed potential benefits in tasks like digit span and verbal fluency, which support enhanced focus and performance.
These findings validate Huperzine A’s role in Intellectra for improving cognitive performance in both mental and physical activities.
Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease
Summary:
This double-blind study found that Huperzine A significantly improved cognitive function and task-switching abilities in patients with Alzheimer’s disease over eight weeks.
Participants showed marked improvement in cognitive tests compared to their baseline performance.
These findings support Huperzine A’s inclusion in Intellectra for enhancing memory and cognitive flexibility.
Link to study
PHOSPHATIDYLSERINE
A phospholipid found in high concentrations in the brain, Phosphatidylserine plays an essential role in cell membrane function and neuronal communication. It has been studied for its potential to support working memory, attention, and cognitive resilience, particularly under conditions of stress or aging.
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Summary:
This systematic review and meta-analysis found that phosphatidylserine supplementation (200–300 mg/day) significantly reduced symptoms of inattention in children with ADHD compared to placebo.
The effects on hyperactivity and impulsivity were not statistically significant, though the overall evidence suggests potential benefits for attention regulation.
These findings support phosphatidylserine's inclusion in Intellectra to enhance focus and attention.
Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model
Summary:
This study found that phosphatidylserine supplementation improved memory function and protected brain cells from neurotoxin-induced damage in a rat model. The treatment enhanced learning performance, increased acetylcholine activity in the hippocampus, and elevated glucose uptake in the frontal lobe.
These findings support phosphatidylserine’s inclusion in Intellectra for its neuroprotective benefits and cognitive enhancement.
Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints
Summary:
This double-blind, randomized controlled study found that phosphatidylserine supplementation (100–300 mg/day) significantly improved memory function, particularly delayed verbal recall, in elderly individuals with mild cognitive impairment over six months.
The treatment was well-tolerated with no observed side effects.
These results support the inclusion of phosphatidylserine in Intellectra for enhancing memory and cognitive health.
The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial
Summary:
This randomized, double-blind trial found that phosphatidylserine supplementation (200 mg/day) significantly improved ADHD symptoms, short-term memory, and working memory in children aged 4-14 over two months.
Participants also showed better attention and mental performance in cognitive tasks.
These results support phosphatidylserine’s inclusion in Intellectra to enhance memory, focus, and cognitive function.
L-TYROSINE
An amino acid naturally found in protein-rich foods like dairy, eggs, and fish, L-Tyrosine is a precursor to dopamine, norepinephrine, and epinephrine, neurotransmitters involved in motivation, stress response, and cognitive flexibility.
It plays a key role in helping maintain mental performance during periods of stress or fatigue.
Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course
Summary:
This study demonstrates that L-Tyrosine supplementation improves cognitive performance and reduces blood pressure under intense stress conditions. Military cadets who received 2g of L-Tyrosine daily during a demanding combat training course showed enhanced memory, tracking task performance, and lower systolic blood pressure compared to a control group.
These findings further validate L-Tyrosine’s role in Intellectra, supporting mental endurance, stress resilience, and cognitive function under high-pressure environments.
L-Tyrosine to alleviate the effects of stress?
Summary:
This study highlights L-Tyrosine as a precursor to catecholamines (dopamine, norepinephrine, and epinephrine), playing a critical role in stress resilience and cognitive function.
Research from military studies and universities suggests that L-Tyrosine may help alleviate stress-related cognitive decline by maintaining neurotransmitter levels under demanding conditions.
These findings reinforce L-Tyrosine’s inclusion in Intellectra, ensuring sustained mental performance, focus, and stress resilience, especially in high-pressure situations.
Tyrosine improves working memory in a multitasking environment
Summary:
This study demonstrates that L-Tyrosine enhances working memory in high-stress, multitasking environments. Participants who consumed 150 mg/kg of L-Tyrosine showed improved accuracy and reduced memory retrieval errors during a demanding cognitive task, compared to a placebo group.
These findings support L-Tyrosine’s role in Intellectra, helping users maintain peak cognitive function under pressure, sustain mental clarity, and perform efficiently in complex, multitasking situations.
Link to study
Tyrosine supplementation mitigates working memory decrements during cold exposure
Summary:
This study shows that L-Tyrosine helps sustain cognitive performance under extreme environmental stress, such as cold exposure. Participants given 300 mg/kg of L-Tyrosine performed significantly better on memory and reaction time tasks, even when exposed to low temperatures that typically impair cognition.
These findings support L-Tyrosine’s inclusion in Intellectra, ensuring users maintain focus, mental clarity, and processing speed even in high-stress or extreme conditions.
PIPERINE
A bioactive compound derived from black pepper (Piper nigrum), Piperine is primarily known for its ability to enhance nutrient absorption by modulating enzymes involved in metabolism. It has been shown to increase the bioavailability of certain compounds, making it a valuable addition to formulations containing various nootropic ingredients.
Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
Summary:
This study demonstrates that piperine significantly enhances bioavailability by increasing the absorption and serum concentration of compounds like curcumin.
In humans, piperine increased bioavailability by 2000%, confirming its role as a powerful absorption enhancer.
These findings support its inclusion in Intellectra to maximize the effectiveness of key nootropic ingredients by improving their uptake and utilization in the body.
Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease
Summary:
This study highlights piperine’s neuroprotective effects, demonstrating its ability to reduce cognitive deficits in a mouse model of Alzheimer’s disease.
Piperine ameliorated oxidative stress, restored neurotransmission, and reduced neuroinflammation, all of which contribute to cognitive decline.
These findings reinforce piperine’s role not only as a bioavailability enhancer but also as an active cognitive support compound, making it a valuable addition to Intellectra for its dual benefits in absorption enhancement and neuroprotection.
Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper and Potential Applications
Summary:
This study highlights piperine from black pepper as a bioavailability enhancer, improving the absorption of vitamins, minerals, and other nutrients.
It is particularly beneficial for optimizing iron levels, which are crucial for oxygen transport, endurance, and muscle recovery.
These findings support piperine’s inclusion in Intellectra to enhance nutrient absorption and maximize the effectiveness of its cognitive-boosting ingredients.
CITOCOLINE
Citicoline is a compound naturally present in the brain that serves as a key building block for phospholipids, which help maintain the integrity of brain cell membranes.
It has been studied for its role in supporting cognitive processing speed, attention, and overall brain energy metabolism.
Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy
Summary:
This study reinforces the cognitive benefits of Citicoline (Cognizin) by showing its ability to enhance frontal lobe bioenergetics and phospholipid membrane turnover, which are crucial for memory, attention, and overall brain function.
The increase in ATP (+14%) and phosphocreatine to inorganic phosphate ratio (+32%) indicates improved energy metabolism in the brain, which supports sustained mental performance.
These findings strongly validate Citicoline’s role in Intellectra’s formula, emphasizing its benefits for cognitive longevity, focus, and neuroprotection.
Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Summary:
This randomized, double-blind, placebo-controlled trial confirms the effectiveness of Citicoline in improving memory function in older adults with age-associated memory impairment (AAMI). The study highlights significant gains in episodic memory after 12 weeks of supplementation compared to the placebo group.
For Intellectra, this further supports Citicoline’s role in enhancing cognitive function, memory retention, and neuroprotection, making it a compelling ingredient for individuals seeking long-term brain health and peak mental performance.
Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis
Summary:
This systematic review and meta-analysis supports the role of Citicoline in improving cognitive function in individuals with mild cognitive impairment, Alzheimer's disease, and post-stroke dementia.
The results indicate a positive effect of Citicoline on cognitive status, making it a promising agent for brain health, neuroprotection, and cognitive enhancement.
For Intellectra, this reinforces Citicoline’s potential in long-term cognitive support, neuroplasticity, and memory retention, positioning it as a strong component of the nootropic blend aimed at both short-term mental clarity and long-term brain health preservation.
Citicoline improves verbal memory in aging
Summary:
This study demonstrates that citicoline supplementation enhances verbal memory in aging adults, particularly those with baseline memory inefficiencies.
The findings indicate that citicoline significantly improves delayed recall, with measurable increases in plasma choline levels over time.
Given its role in supporting frontal lobe bioenergetics and phospholipid metabolism, citicoline is a valuable addition to Intellectra, reinforcing its ability to boost memory retention and cognitive function for those looking to optimize mental performance.
Link to study
CAFFEINE
A naturally occurring stimulant found in coffee beans, tea leaves, and cacao, Caffeine temporarily blocks adenosine receptors, reducing feelings of fatigue and promoting alertness.
It has been shown to enhance reaction time, attention, and cognitive endurance, particularly when combined with L-Theanine to help smooth out its stimulating effects.
The effects of low doses of caffeine on human performance and mood
Summary:
This study demonstrates that even low doses of caffeine (as little as 32 mg) significantly enhance auditory vigilance and reaction time without causing adverse effects such as anxiety or impaired motor performance. These findings support caffeine’s role as a mild yet effective cognitive enhancer, making it an ideal ingredient in Intellectra for improving focus, alertness, and mental clarity while minimizing jitteriness.
The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review
Summary:
This systematic review highlights the synergistic cognitive benefits of caffeine and L-theanine, particularly in improving attention, mental focus, and cognitive processing. Caffeine works by blocking adenosine receptors, increasing alertness and dopamine transmission, while L-theanine enhances relaxation without drowsiness, acting as a glutamate receptor antagonist and promoting neuroprotection via GABA-A receptors. These findings reinforce Intellectra’s formulation, combining these two ingredients to maximize focus and mental clarity while reducing overstimulation or jitters.
The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review
Summary:
This systematic review highlights the cognitive-enhancing synergy of caffeine and L-theanine, particularly in improving attention, focus, and cognitive control. Caffeine enhances dopaminergic and cholinergic neurotransmission, while L-theanine acts as a glutamate receptor antagonist, promoting a calm yet alert state.
This dual mechanism makes the combination ideal for boosting sustained focus and mental clarity without jitteriness.
These findings strongly support their inclusion in Intellectra to optimize cognitive performance and attentional control.